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KMID : 0613820220320080589
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Journal of Life Science
2022 Volume.32 No. 8 p.589 ~ p.594
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Betulinic Acid Ameliorates Postprandial Hyperglycemia in Diabetic Mice
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Lee Jung-Kyung
Lee Hyun-Ah
Han Ji-Sook
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Abstract
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The objective of this study was to investigate whether betulinic acid can inhibit the activities of carbohydrate-digesting enzymes and reduce postprandial hyperglycemia in mice with streptozotocin-induced diabetes. Our results revealed that betulinic acid has potent inhibitory effects on α-glucosidase and α-amylase activities. The half-maximal inhibitory concentrations (IC50) of betulinic acid were 12.83± 6.81 and 18.32±3.24 μM for α-glucosidase and α-amylase, respectively. This result indicates lower IC50 values and higher inhibitory activities than those of acarbose, an oral hypoglycemic drug. The increase in postprandial blood glucose levels was significantly suppressed in the betulinic acid group than in the control group of diabetic and normal mice. Postprandial blood glucose levels were 23.22 ±1.1, 24.38±1.31, and 21.05±1.36 μM in the betulinic acid group compared to 24.64±1.7, 27.22±1.58, and 26.36±1.40 μM in the control group of diabetic mice at 30, 60 and 120 min, respectively. The area under the curve also significantly decreased with the administration of betulinic acid in diabetic mice, however, it did not decrease more than that after acarbose administration. Our results showed that betulinic acid may be a potent inhibitor of carbohydrate-digesting enzymes and ameliorate postprandial hyperglycemia in diabetic mice.
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KEYWORD
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Betulinic acid, diabetic mice, postprandial hyperglycemia, α-glucosidase, α-amylase
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